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11 Mar, 26
New guidelines on pulmonary embolism (PE) offer evidence based recommendations for evaluating, managing, and following up adults with acute PE. Endorsed by eight societies, it stresses multidisciplinary care across emergency, inpatient, & outpatient settings.
26 Feb, 26
ADA 2026 outlines the standards for obesity pharmacotherapy. It recommends combining person-centered medication with lifestyle changes for adults with obesity. It details weight-loss targets and drug benefits for comorbidities
12 Mar, 26
Diabetes Obes Metab.
- In a US case–control study (39,281 T2DM cases, 58,751 controls), predictors of progression from prediabetes to T2DM included age 35–64 (OR 1.33–1.49 vs. 18–34), obesity (OR 1.45), CVD (OR 1.64), OSA (OR 1.36), MASH (OR 1.37), & neuropathy (OR 1.19)
- American-Africans (OR 1.27) & Hispanic (OR 1.21) patients had higher odds vs. White (p<0.0001)
- These comorbidities highlight key risk factors for T2DM progression.
12 Mar, 26JAMA Cardiol.
- In a Danish cohort (n=38455; biomarker subcohort n≈2,056, age 30.4 y), 28 women (1.4%) developed CVD over median 11.9 y
- Third trimester hs cTnI & soluble fms-like tyrosine kinase-1 (sFlt-1), maternal age, & HDPs independently predicted risk, a week 29 model (age+sFlt 1) improved discrimination vs. age alone (ΔAUC 0.16)
- Pregnancy biomarkers may be good sex specific predictors for long term CVD prevention.
11 Mar, 26JAMA Neurol.
- Dengue increased acute neurological events risk at 30 days vs uninfected cases: any new-incident neurological event (OR 9.69), memory loss (OR 3.19), movement disorders (OR 7.10), other neurological disorders (fatigue, encephalitis OR 14.32)
- Excess burden was modest (<1 excess event/100 cases)
- Risk was higher in adults ≥60 yrs & during DENV serotype 3 transmission (memory loss OR 2.99, movement disorders OR 6.38)
10 Mar, 26Diabetes Res Clin Pr...
- In CHARLS (age ≥45, no prior stroke), baseline remnant cholesterol (RC) quartiles predicted 7 yr incident stroke (9.44%), adjusted HRs vs. Q1: 1.23, 1.39, 1.42
- Risk was significant in prediabetes & diabetes but not amongst those with normal glucose regulation, the risk was stronger when LDL C <130 mg/dL
- High RC independently predicted stroke in dysglycemia, suggesting it to be a therapeutic target beyond LDL C.
2 Mar, 26
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